High-yielding metalloenzymatic dynamic kinetic resolution of fluorinated aryl alcohols |
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| Authors: | Krisztián Bogár |
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| Institution: | Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden |
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| Abstract: | Dynamic kinetic resolution (DKR) of various fluorinated aryl alcohols by a combination of lipase-catalyzed enzymatic resolution with in situ ruthenium-catalyzed alcohol racemization is described. (R)-Selective Candida antarctica lipase B (CALB) was employed for transesterification of different fluoroaryl alcohols in DKR reactions delivering the corresponding acetates in high yield (?97%) with excellent enantiomeric excess (?98%). |
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