A simple one-pot, three-component, catalytic, highly enantioselective isoxazolidine synthesis |
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| Authors: | Ramon Rios |
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| Affiliation: | Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden |
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| Abstract: | The highly chemo- and enantioselective organocatalytic three-component reaction between N-arylhydroxylamines, aldehydes and α,β-unsaturated aldehydes is presented; the reaction gives access to isoxazolidines in high yields with >25:1 dr and 91-99% ee. |
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