Trisorbicillinone A, a novel sorbicillin trimer, from a deep sea fungus, Phialocephala sp. FL30r |
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| Authors: | Dehai Li Xiang Xiao Tianjiao Zhu Weiming Zhu |
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| Institution: | a Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, PR China
b Beijing Key Laboratory of Marine Biogenetic Resources, The Third Institute of Oceanography, The State Oceanic Administration, Xiamen, PR China |
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| Abstract: | A novel sorbicillin trimer, trisorbicillinone A (1), was isolated from a deep sea fungus, Phialocephala sp. FL30r. The structure and relative stereochemistry of 1 were determined based on spectroscopic methods. Trisorbicillinone A (1) showed cytotoxicity against P388 and HL60 cells with the IC50 value of 9.10 and 3.14 μM, respectively. |
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| Keywords: | Phialocephala sp Trisorbicillinone A Cytotoxicity Fungus |
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