One-pot synthesis of functionalized hydantoin derivatives via a four-component reaction between an amine, an arylsulfonyl isocyanate and an alkyl propiolate or dialkyl acetylenedicarboxylate in the presence of triphenylphosphine |
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Authors: | Abdolali Alizadeh Ehsan Sheikhi |
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Institution: | Department of Chemistry, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran |
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Abstract: | An effective route to functionalized hydantoin derivatives is described, involving the reaction of a urea derivative resulting from the addition of a primary amine to an arylsulfonyl isocyanate, and an alkyl propiolate or dialkyl acetylenedicarboxylate in the presence of triphenylphosphine. The reactive 1:1 intermediate obtained from the addition of triphenylphosphine to the alkyl propiolate or dialkyl acetylenedicarboxylate was trapped by NH-acids such as the urea derivative to produce functionalized hydantoin derivatives. |
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Keywords: | Alkyl propiolate Amine Arylsulfonyl isocyanate Dialkyl acetylenedicarboxylate Hydantoin Triphenylphosphine Multicomponent reaction |
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