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An efficient synthesis of 2-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)morpholine: a potent M1 selective muscarinic agonist
Authors:YC Sunil Kumar
Institution:Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India
Abstract:2-(1-Methyl-1,2,5,6-tetrahydropyridin-3-yl)morpholine is useful for synthesizing potent antimicrobials including the arecoline derivatives, phendimetrazine and polygonapholine and was synthesised in nine steps with an overall yield of 36%. Bromination of 3-acetylpyridine and dehydration of a diol with cyclization were pivotal to the success of the strategy.
Keywords:C-Substituted morpholines  2-Acetyl pyridine  Arecoline
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