Concise syntheses of immunostimulating glycolipids, α-galactosyl ceramides |
| |
| Authors: | Takashi Tsujimoto Yukishige Ito |
| |
| Affiliation: | a RIKEN (The Institute of Physical and Chemical Research), Discovery Research Institute, 2-1 Hirosawa, Waki, Saitama 351-0198, Japan
b RIKEN, Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohamai, Kanagawa 230-0045, Japan |
| |
| Abstract: | α-Galactosylceramides (α-GalCers) are well known as immunostimulating agents having therapeutic potential. To facilitate the synthesis of α-GalCers and their derivatives, a novel and convergent strategy was designed, which is expected to be versatile for the preparation of a variety of analogues in a diversity-oriented fashion. As an initial demonstration of our strategy, KRN7000 and OCH were synthesized in eight steps from a common intermediate, which is easily obtainable in a multi-gram scale. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
