Straightforward one-pot stereoselective synthesis of substituted tetrahydrofurans from 1,3-butadienes and aldehydes |
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| Authors: | Maryline Roux Maurice Santelli |
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| Affiliation: | Laboratoire de Synthèse Organique, Campus Scientifique de St-Jérôme, Service 541, Aix-Marseille Université, Avenue Escadrille Normandie-Niemen, 13397 Marseille Cedex 20, France |
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| Abstract: | A new and efficient multicomponent reaction involving a double-allylation sequence is reported. In situ generated bimetallic reagents are prepared from disilane 1 and added onto a range of aliphatic aldehydes to afford a direct access to trisubstituted tetrahydrofurans in good to excellent diastereoselectivity (up to 70%). |
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