Synthesis of pyridine-based polyaminocarboxylic ligands bearing a thioalkyl anchor |
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| Authors: | Yi Lin,Sté phane Pellet-Rostaing,Marc Lemaire |
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| Affiliation: | a ICBMS, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, Laboratoire de Catalyse et Synthèse Organique, 43 boulevard du 11 novembre 1918, Villeurbanne F-69622, France; CNRS, UMR5246, Villeurbanne F-69622, France; Université de Lyon, Lyon F-69622, France; Université Lyon 1, Lyon F-69622, France; INSA-Lyon, Villeurbanne F-69622, France; CPE Lyon, Villeurbanne F-69616, France
b Laboratoire de Chimie organique, UMR CNRS 7084, Conservatoire des Arts et Métiers, 2 rue Conté, 75003 Paris, France |
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| Abstract: | A bicyclic tetraazatriacetic chelating agent containing a thioalkyl pendant group was prepared. Four synthetic routes have been investigated via a Mitsunobu reaction from 2,4-[bishydroxymethyl]-3-hydroxy-pyridine 1. Deprotection of trityl thioether compound 5c led to ligand 6c in 22% overall yield from the starting 3-hydroxypyridine. |
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| Keywords: | Azamacrocycle PCTA Mitsunobu reaction Thiol |
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