Synthesis of an octahydroindolinone scaffold for a diversity-based chemical compound library |
| |
Authors: | Gregg F. Keaney Charles W. Johannes |
| |
Affiliation: | Infinity Pharmaceuticals, Inc., 780 Memorial Drive, Cambridge, MA 02139, USA |
| |
Abstract: | The synthesis of a chemical compound library using diversity-oriented synthesis (DOS) is discussed. The library is structurally inspired by the Amaryllidaceae alkaloids, a family of natural products which has been known to demonstrate potent antiviral and antineoplastic activity. Highlights of this work include the rapid, high-yielding construction of the octahydroindolinone core and the solid-phase diversification of the lactam using a neutral phosphazene base. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|