Radical-mediated synthesis of 3,4-dihydroisocoumarins: total synthesis of hydrangenol |
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Authors: | Samir Kumar Mandal |
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Institution: | Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India |
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Abstract: | A radically promoted synthesis of 3,4-dihydroisocoumarins has been achieved in moderate to good yields using titanocene(III) chloride (Cp2TiCl) as the radical initiator. The total synthesis of (±)-hydrangenol has been completed using this radical technology. Cp2TiCl was prepared in situ from commercially available titanocene dichloride (Cp2TiCl2) and Zn-dust in THF under argon. |
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Keywords: | Titanocene(III) chloride Radical reaction 3 4-Dihydroisocoumarins Hydrangenol |
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