TMSCl-promoted isocyanide-based MCR of ethylenediamines: an efficient assembling of 2-aminopyrazine core |
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| Authors: | Volodymyr Kysil Sergey Tkachenko Caroline Williams Marina Churakova |
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| Affiliation: | a ChemDiv, Inc., 6605 Nancy Ridge Dr., San Diego, CA 92121, USA
b Chemical Diversity Research Institute, 114401 Khimki, Moscow Reg., Russia |
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| Abstract: | New trimethylchlorosilane (TMSCl) promoted multicomponent reaction (MCR) of ethylenediamine(s), diverse carbonyl compounds, and isocyanides is proposed for the synthesis of a variety of highly substituted 3,4,5,6-tetrahydropyrazin-2-amines including corresponding spirocyclic compounds. |
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| Keywords: | Multicomponent reaction (MCR) Isocyanide Aminopyrazine Pyrazine ring synthesis Trimethylchlorosilane (TMSCl) |
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