| 多乙酰氧基烷基卓酮的合成 |
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| 引用本文： | 尹炳柱,森章,竹下齐.多乙酰氧基烷基卓酮的合成[J].有机化学,2000,20(4):522-528. |
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| 作者姓名： | 尹炳柱 森章 竹下齐 |
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| 作者单位： | [1]延边大学化学系 [2]九州大学机能物质研究所 |
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| 摘 要： | 各种溴代的烷基卓酚酮的乙酸酯用乙酸酐/三氟乙酸酐/乙酸(以下简称ATA)醋解可得高收率的相应的多乙酰氧基烷基卓酮，后者经稀酸水解几乎定量地得多羟基烷基卓酮。部分多乙酰氧基卓酮对肺癌A~5~4~9和上皮细胞癌显出抑制活性。
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| 关 键 词： | 卓酮 乙酰氧基 醋解 乙酸酐 乙酸 三氟乙酸酐 生理生化特性 |
Synthesis of polyacetoxyalkyltropones and polyhydroxyalkyltropones |
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| Abstract: | In this paper, a series of polyacetoxyalkyltropones and polyhydroxyalkyltroponeswere synthesized by the reaction of polybromo- substituted alkyltropolones with acetyl trifuluoroacetate. The results of preliminary pharmacological test indicated that some poly- acetoxyalkyltropones had the inhibition effect against cells of KB and A549 in vitro. |
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| Keywords: | ACETOXY GROUP ACETOLYSIS ACETIC ANHYDRIDE ACETIC ACID PHYSICOCHEMICAL CHARACTERISTICS |
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