| 合成1,2-环十二二酮的新方法 |
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| 引用本文： | 陈韶蕊,马吉海,周雪琴,刘东志.合成1,2-环十二二酮的新方法[J].应用化学,2009,26(11):1374-1376. |
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| 作者姓名： | 陈韶蕊 马吉海 周雪琴 刘东志 |
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| 作者单位： | (1.天津大学化工学院 天津 300072；2.河北科技大学理学院 石家庄) |
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| 摘 要： | 以十二烷二酸（１）为原料，与甲醇酯化生成十二烷二酸二甲酯（２），收率为８６５％。化合物２经偶联
缩合得１，２ 二三甲基硅氧基环十二烯（３），收率为６３１％。利用溴氧化化合物３得到１，２ 环十二二酮（４）淡黄色晶体，收率７９％，全过程收率达４３.１％，是合成１，２ 二酮的新方法。目标化合物结构经红外光谱、核磁共振氢谱和碳谱表征确认。
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| 关 键 词： | 十二烷二酸 偶姻缩合 1 2-环十二二酮 |
| 收稿时间： | 2008-10-29 |
| 修稿时间： | 2009-03-05 |
A Novel Synthetic Method for 1,2-Cyclododecandione |
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| CHEN Shao-Rui,MA Ji-Hai,ZHOU Xue-Qin,LIU Dong-Zhi.A Novel Synthetic Method for 1,2-Cyclododecandione[J].Chinese Journal of Applied Chemistry,2009,26(11):1374-1376. |
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| Authors: | CHEN Shao-Rui MA Ji-Hai ZHOU Xue-Qin LIU Dong-Zhi |
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| Institution: | (1.School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072;
2.College of Science,Hebei University of Science and Technology,Shijiazhuang) |
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| Abstract: | 1,2-Cyclododecandione (4) was synthesized from dodecanedioic acid via esterification, acyloin condensation, oxidation in an overall yield of 43. 1 %. Reaction of dodecanedioic acid with methanol gave dodecanedioic acid dimethyl ester(2) with a yield of 86. 5%. Compound 3 was obtained from compound 2 through acyloin condensation and the yield reached up to 63. 1% , which was oxidized to compound 4 by bromine water as the oxidation reagent with a yield of 79%. The target compound was a light yellow crystal and was characterized by means of IR, ~1H NMR and ~(I3)C NMR. |
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| Keywords: | dodecanedioic acid acyloin condensation cyclododecandione |
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