Lipophilic derivatives of cyclam as new inhibitors of tumor cell growth |
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Authors: | Sibert John W Cory Ann H Cory Joseph G |
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Affiliation: | Department of Chemistry, University of Texas at Dallas, P.O. Box 830688, Richardson, TX 75083-0688, USA. sibertj@utdallas.edu |
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Abstract: | Two new lipophilic tetraazamacrocycles were prepared and, in contrast to non-lipophilic analogs, found to be potent inhibitors of tumor cell growth in vitro with IC50 values below 10 micromolar. |
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