Titanium-catalyzed enantioselective alkynylation of aldehydes |
| |
| Authors: | Lu Gui Li Xingshu Chan Wing Lai Chan Albert S C |
| |
| Affiliation: | Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong Polytechnic University, Hong Kong. |
| |
| Abstract: | A simple and practical method to make chiral propargylic alcohols has been developed: in the presence of a titanium alkoxide catalyst prepared in situ from titanium tetraisopropoxide and (R)-H8-binaphthol, a variety of aromatic aldehydes were converted to the corresponding chiral propargylic alcohols with very good enantioselectivities (up to 96.2% e.e.) and yields. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
