Determination of sultopride and tiapride in serum by gas chromatography using a surface ionisation detector |
| |
| Authors: | A Kamizono N Inotsume K Miyamoto K Ueda T Miyakawa H Arimoto M Nakano |
| |
| Institution: | Department of Pharmaceutical Services, Kumamoto University Hospital, Japan. |
| |
| Abstract: | A sensitive and selective method has been developed for the determination of sultopride and tiapride in serum using gas chromatography with a surface ionisation detector. No interfering peaks from endogenous substances were observed. The method showed good reproducibility and accuracy, and the standard curve was linear up to 2 micrograms/ml with a correlation coefficient of 0.999. This method is applicable to pharmacokinetic studies and therapeutic drug monitoring of sultopride and tiapride. |
| |
| Keywords: | |
|
