Oxidation of ascorbic acid in the presence of phthalocyanine metal complexes. Chemical aspects of catalytic anticancer therapy. 1. Catalysis of oxidation by cobalt octacarboxyphthalocyanine |
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| Authors: | E G Girenko S A Borisenkova O L Kaliya |
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| Institution: | (1) Federal State Unitary Enterprise "State Research Center  Research Institute of Organic Intermediate Products and Dyes, ", Building 4, 1 ul. B. Sadovaya, 101999 Moscow, Russian Federation;(2) Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory, Moscow, 119899, Russian Federation |
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| Abstract: | The kinetics of oxidation of ascorbic acid in the presence of cobalt octa-4,5-carboxyphthalocyanine sodium salt (Teraphthal) was studied. A kinetic equation was obtained and a scheme of the process was proposed. According to the scheme, the first stage is the formation of a complex of the catalyst with dioxygen, and the limiting stage is the reaction of dioxygen with the ascorbate monoanion. The influence of the pH of the medium and the presence of a transport protein (albumin) on the state and catalytic activity of Teraphthal was studied. The involvement of hydrogen peroxide and oxygen-centered radicals in the catalytic oxidation of ascorbic acid was proved. |
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| Keywords: | cobalt phthalocyanine ascorbic acid oxidation catalysis anticancer therapy |
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