Synthesis of a 3-deoxy-D-manno-octulosonic acid (KDO) building block from D-glucose via fermentation |
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| Authors: | Camci-Unal Gulden Mizanur Rahman M Chai Yonghai Pohl Nicola L B |
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| Institution: | Department of Chemistry, Iowa State University, Ames, IA 50011-3111, USA. |
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| Abstract: | Herein we report the first synthesis of a 3-deoxy-D-manno-octulosonic acid (KDO) building block starting from glucose through pathway engineering of Escherichia coli and subsequent chemical modifications to provide an alternative method to produce KDO, found in plant and bacterial oligosaccharides. |
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