| 稀土掺杂无机纳米晶及其时间分辨荧光生物检测应用 |
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| 引用本文： | 张文,黄萍,委娇娇,郑伟,陈学元. 稀土掺杂无机纳米晶及其时间分辨荧光生物检测应用[J]. 中国稀土学报, 2021, 0(1): 35-57 |
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| 作者姓名： | 张文 黄萍 委娇娇 郑伟 陈学元 |
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| 作者单位： | 中北大学理学院;中国科学院福建物质结构研究所;中国福建光电信息科学与技术创新实验室（闽都创新实验室） |
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| 基金项目： | 中国科学院创新国际团队项目;国家自然科学基金促进海峡两岸科技合作联合基金项目(U1805252);国家自然科学基金面上项目(21771185,21875250,11774345)资助。 |
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| 摘 要： | 时间分辨荧光生物标记作为一种灵敏的非放射性标记技术,在科研及医疗机构已获得广泛应用.传统的时间分辨荧光标记以稀土螯合物作为分子探针,存在着光化学稳定性差、长期生物毒性以及价格昂贵等缺点.稀土掺杂无机纳米晶因其优异的光化学与光物理性能,是目前普遍看好且有望成为替代稀土螯合物的新一代时间分辨纳米荧光探针.利用稀土纳米探针的...
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| 关 键 词： | 稀土发光 时间分辨荧光 纳米探针 生物检测 疾病标志物 |
Lanthanide-Doped Inorganic Luminescent Nanocrystals and Their Application for Time-Resolved Luminescent Biodetection |
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| Zhang Wen,Huang Ping,Wei Jiaojiao,Zheng Wei,Chen Xueyuan. Lanthanide-Doped Inorganic Luminescent Nanocrystals and Their Application for Time-Resolved Luminescent Biodetection[J]. Journal of the Chinese Society of Rare Earths, 2021, 0(1): 35-57 |
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| Authors: | Zhang Wen Huang Ping Wei Jiaojiao Zheng Wei Chen Xueyuan |
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| Affiliation: | (College of Science,North University of China,Taiyuan 030051,China;CAS Key Laboratory of Design andAssembly of Functional Nanostructures,Fujian Key Laboratory of Nanomalerials,and Stale Key Labo-ratory of Structural Chemistry,Fujian Instiute of Research on the Structure of Matter,Chinese Acade-my of Sciences,Fuzhou 350002,China;Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China,Fuzhou 350108,China) |
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| Abstract: | Time-resolved(TR)photoluminescence(PL)biosensing,as a sensitive and non-radioactive biosensing technique,has been widely adopted in many research and medical institutions.However,conventional TRPL biosensing utilizing lanthanide(Ln3+)chelates as molecular probes suffers from poor photochemical stability,long-term toxicity and high cost of bioprobes.Inorganic Ln3+-doped nanocrystals(NCs),owing to their superior physicochemical properties,are regarded as a new generation of luminescent nanoprobes and as an alternative to Ln3+-chelates for TRPL biosensing.The long-lived PL of Ln3+-doped NCs combined with the TRPL technique can effectively eliminate the interference of the short-lived background noise,resulting in a remarkably improved signal-to-noise ratio and thereby detection sensitivity for biosensing.In this review,we summarize the latest advancements in inorganic Ln3+-doped luminescent NCs as TRPL nano-bioprobes from their unique optical properties to their potential applications for ultrasensitive biodetection.Future prospects and efforts towards this emerging field are also envisioned. |
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| Keywords: | lanthanide luminescence time-resolved photoluminescence nanoprobe biodetection disease marker |
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