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| Dynamic Simulation of Single DNA Molecule at the Base Level | |
| 作者姓名： | 雷晓玲 王晓峰 胡钧 方海平 |
| 作者单位： | [1]ShanghaiInstituteofAppliedPhysics,ChineseAcademyofSciences,POBox800-204,Shanghai201800／／GraduateSchooloftheChineseAcademyofSciences,Beijing100039 [2]ShanghaiInstituteofAppliedPhysics,ChineseAcademyofSciences,POBox800-204,Shanghai201800／／Bio-XLifeSciencesResearchCenter,ShanghaiJiaoTongUniversity,Shanghai200030 [3]ShanghaiInstituteofAppliedPhysics,ChineseAcademyofSciences,POBox800-204,Shanghai201800 |
| 摘 要： | A mesoscopic discrete dsDNA model at the base level is proposed based on the statistical model (Phys. Rev. Lett.82 (1999) 4560). The numerical simulations reproduce the 65 pN plateau and those on the force vs extension for different supercoiling degrees are favourable with the experimental data. Our model has potential applications on the study of short DNA segments and provides a bridge between the statistical models and atomic modelling. |
| 关 键 词： | DNA分子 力学仿真 离散模型 能级计算 弹性问题 |
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