Calix[4]arenes containing benzodiazepinone fragments at the lower rim |
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| Authors: | E. A. Alekseeva K. S. Andronati A. V. Mazepa A. I. Gren’ T. V. Pavlovskaya I. A. Kravchenko V. I. Bozhanov |
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| Affiliation: | (1) Bogatskii Physicochemical Institute, National Academy of Sciences of Ukraine, Lyustdorfskaya doroga 86, Odessa, 65080, Ukraine;(2) Mechnikov Odessa National University, Ministry of Education and Science of Ukraine, Odessa, Ukraine;(3) Dnepropetrovsk National University, Ministry of Education and Science of Ukraine, Dnepropetrovsk, Ukraine |
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| Abstract: | A series of p-tert-butylcalix[4]arene derivatives containing 1,4(1,5)-benzodiazepinone fragments as substituents were prepared. The biological activity of the compounds, namely, their antispasmodic activity in mice, was evaluated by antagonism with a spasmodic agent, Corazol, upon transdermal administration. According to the data obtained, benzodiazepine derivatives of calixarenes show higher antispasmodic activity compared to 3-hydroxyphenazepam, taking into account their considerably higher molecular weight. |
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