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Cerebral ischemic injury model of rat demonstrated withT 2-weighted magnetic resonance imaging
Authors:G. L. Ding  H. B. Hu  L. Y. Li  C. H. Ye  J. W. Zhang  E. T. Tong
Affiliation:1. Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, People’s Republic of China
2. Union Hospital, Tongji Medical University, Wuhan, People’s Republic of China
Abstract:A photochemical reaction model of focal cerebral ischemic injury of rat was demonstrated by means of enhancedT 2-weighted magnetic resonance imaging. The cerebral ischemia model was made using vein injection of rose bengal and irradiation by a beam of a cw laser with the wave-length of 514 nm. The ischemic injury region in rat brain can be found clearly in theT 2-weighted magnetic resonance images in one hour, this time was calculated from the beginning of the laser irradiation to the end of the NMR data acquisition. It suggests thatT 2-weighted imaging can find cerebral ischemia earlier than several hours after the onset of ischemia given in other papers. It also confirms that theT 2-weighted magnetic resonance imaging approach should be of great potential to be applied in studying the cerebral ischemia.
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