| 3,4-二胺-1H-吡唑并[5,4-d]嘧啶的固相合成 |
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| 引用本文： | 谢君,马月龙,肖元晶,杨琍苹. 3,4-二胺-1H-吡唑并[5,4-d]嘧啶的固相合成[J]. 有机化学, 2004, 24(11): 1436-1439 |
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| 作者姓名： | 谢君 马月龙 肖元晶 杨琍苹 |
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| 作者单位： | 华东师范大学化学系,上海,200062 |
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| 摘 要： | 用固相合成技术合成了吡唑并[5,4-d]嘧啶的一类衍生物8.以Merrifield树脂为原料,与化合物3反应得到树脂4.4经过还原胺化、取代、分子内亲核加成反应得到树脂7,再由三氟醋酸断裂得到化合物3,4-二胺-1H-吡唑并[5,4-d]嘧啶.
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| 关 键 词： | 固相合成 吡唑并[5 4-d]嘧啶 树脂 连接臂 |
| 修稿时间： | 2003-10-27 |
Solid-Phase Synthesis of 3,4-Diamino-1H-pyrazolo[5,4-d] pyrimidines |
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| XIE,Jun MA,Yue-Long XIAO,Yuan-Jing YANG,Li-Ping. Solid-Phase Synthesis of 3,4-Diamino-1H-pyrazolo[5,4-d] pyrimidines[J]. Chinese Journal of Organic Chemistry, 2004, 24(11): 1436-1439 |
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| Authors: | XIE Jun MA Yue-Long XIAO Yuan-Jing YANG Li-Ping |
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| Abstract: | An efficient method for the solid-phase synthesis of various substituted pyrazolo[5,4-d]pyrimidine (8) was described. Merrifield resin was used as a starting material to react with compound 3 giving resin 4. The resin 4 was followed by reductive amination, substitution, intramolecular nucleophilic addition to afford resin 7. Cleavage from the resin using trifluroactic acid gave the desired 3,4-diamino-1H-pyrazolo [5,4-d]pyrimidines. |
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| Keywords: | solid-phase synthesis pyrazolo[5 4-d]pyrimidine resin linker |
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