Studies of CoQ10 and cyclodextrin complexes: solubility, thermo- and photo-stability |
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Authors: | Maja Milivojevic Fir Andrej Smidovnik Luka Milivojevic Janko Zmitek Mirko Prosek |
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Institution: | 1. National Institute of Chemistry, Hajdrihova 19, 1000, Ljubljana, Slovenia
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Abstract: | The complexes of coenzyme Q10 with β- and γ-cyclodextrin in aqueous solutions were prepared in order to improve the water solubility, thermo- and photo-stability of coenzyme Q10. Complex formation resulted in an increase in water solubility at room temperature and pH 6.5 by a factor at least 102. The solubility of coenzyme Q10 in the presence of cyclodextrins linearly increases with temperature and pH. The UV light (λ = 254) and temperature together have a great effect on coenzyme Q10 stability. After 120 min of exposure at 80 °C and UV light about 72.3% of pure coenzyme Q10 was degraded. Thermo- and photo-stability was strongly improved by complex formation; more than 64% of coenzyme Q10 remained unchanged. The formation of complexes was evaluated using IR spectrometry, X-ray diffractometry and TGA/DSC analysis. |
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