Enzyme-catalyzed cascade synthesis of hydroxyiminoacetamides |
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| Authors: | Anamarija Kne?evi? Vladimir Vinkovi? Nikola Marakovi? Goran Šinko |
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| Institution: | 1. Division of Organic Chemistry and Biochemistry, Ru?er Boškovi? Institute, Bijeni?ka 54, HR-10000 Zagreb, Croatia;2. Biochemistry and Organic Analytical Chemistry Unit, Institute for Medical Research and Occupational Health, P.O. Box 291, HR-10000 Zagreb, Croatia |
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| Abstract: | In order to synthesize N-(3-azido-1-phenylpropyl)-2-hydroxyiminoacetamide, a key compound for the preparation of acetylcholinesterase (AChE) reactivators of the N-substituted 2-hydroxyiminoacetamide type, it was necessary to develop a method for forming an amide bond between an ethyl glyoxylate oxime and an amine. Using Candida antarctica lipase B (CAL-B) in a cascade enzyme-BOP catalyzed reaction, the efficient synthesis of the target hydroxyiminoacetamide was achieved. |
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| Keywords: | YJZBBDZRGUXYGR-UHFFFAOYSA-N VMTXWNLNQMPQLB-SNAWJCMRSA-N PSNSMVAWKVZOQN-WOJGMQOQSA-N VSJDCHRSRXXLJP-DNLQIICGSA-N HNVSUUSQYNKMTQ-RIYZIHGNSA-N |
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