Holophyllin A,a rearranged abietane-type diterpenoid from the trunk of Abies holophylla |
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| Authors: | Chung Sub Kim Bora Shin Oh Wook Kwon Sun Yeou Kim Sang Un Choi Dong-Chan Oh Ki Hyun Kim Kang Ro Lee |
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| Institution: | 1. Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-ku, Suwon 440-746, Republic of Korea;2. Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea;3. Graduate School of East-West Medical Science, Kyung Hee University, Yongin 446-701, Republic of Korea;4. Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 406-799, Republic of Korea;5. College of Pharmacy, Gachon University, Incheon 406-799, Republic of Korea;6. Korea Research Institute of Chemical Technology, Daejeon 305-343, Republic of Korea |
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| Abstract: | Holophyllin A (1), a novel rearranged abietane-type diterpenoid was isolated, together with a new diterpene glycoside, holophyllin B (2), from the trunk of Abies holophylla. The structures of 1 and 2 were established by extensive spectroscopic analyses and their absolute configurations were determined by ECD calculation. All the isolates were tested for their inhibitory effects on NO production in LPS-activated murine microglial cells. |
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| Keywords: | Abies holophylla Pinaceae Abietane diterpene Spiro compound |
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