Antimicrobial sesquiterpenes from the Chinese medicinal plant, Chloranthus angustifolius |
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| Authors: | Xinzhou Yang Chao Wang Jing Yang Dingrong Wan Qinxiong Lin Guangzhong Yang Zhinan Mei Yunjiang Feng |
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| Institution: | 1. College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, PR China;2. Eskitis Institute, School of Biomolecular and Physical Sciences, Griffith University, QLD 4111, Brisbane, Australia |
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| Abstract: | Two new eudesmane-type sesquiterpenes, 9α-hydroxycurcolonol (1) and 3α-hydroxy-4-deoxy-5-dehydrocurcolonol (2), along with nine known sesquiterpenes (3–11), were isolated from the roots of Chloranthus angustifolius. The antimicrobial activities of compounds 1–11 were evaluated against five bacteria and six fungal strains. Compounds 6–11 showed potent activities against Candida albicans with MIC values ranging from 4 to 8 μg/mL. The structures of the two new compounds 1 and 2 were established by a detailed analysis of their NMR and mass spectroscopic data. |
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| Keywords: | Chloranthus angustifolius Eudesmane sesquiterpenes Antimicrobial Traditional Chinese medicine |
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