Synthesis of functionalized N-triazolyl maleimides |
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| Authors: | Hélio A Stefani Fernando P Ferreira Bakhat Ali Daniel C Pimenta |
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| Institution: | 1. Departamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, SP, Brazil;2. Departamento de Biofísica, Universidade Federal de São Paulo, São Paulo, SP, Brazil;3. Laboratório de Bioquímica e Biofísica, Instituto Butantan, São Paulo, SP, Brazil |
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| Abstract: | An easy and mild two-step one-pot reaction allowed the synthesis of functionalized N-triazolyl maleimide. Next, the addition of propargyl alcohol and propargyl amine to the N-acyliminium ion mediated by Lewis acid, In(OTf)3, allowed the introduction of a second 1,2,3-triazol ring at position 5 of the amide. The products in both reactions were achieved in moderate to good yields. |
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| Keywords: | Maleimide Click chemistry Addition reaction N-Acyliminium ion 1 2 3-Triazole |
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