Design,synthesis, and biological evaluation of indolylidinepyrazolones as potential anti-bacterial agents |
| |
| Authors: | A. Indrasena Sd. Riyaz Prema L. Mallipeddi P. Padmaja B. Sridhar P.K. Dubey |
| |
| Affiliation: | 1. Department of Chemistry, J.N.T. University Hyderabad, Kukatpally, Hyderabad 500085, India;2. X-ray Crystallography Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India |
| |
| Abstract: | A series of indolylidinepyrazolones were synthesized using a simple, green, and effective route and evaluated as anti-bacterial agents. The compounds were further studied via structure-guided docking study. One of the compounds exhibiting H-bonding interactions with conserved residue Arg144 turned out to be the most potent compound of the series. The minimum inhibitory concentration values ranged from 50 to 25 μg/mL against Staphylococcus aureus in their anti microbial evaluation. |
| |
| Keywords: | Indole-3-carboxaldehyde Pyrazolone DMF-DMA Knoevenagel condensation DNA gyrase inhibitors |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
