A facile route for the synthesis of novel S-linked 1,3,5-triazine tethered peptidomimetics |
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| Authors: | Muniyappa Krishnamurthy BasavaprabhuKM Sharanabai Vommina V Sureshbabu |
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| Institution: | #109, Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Bangalore University, Dr. B.R. Ambedkar Veedhi, Bangalore 560 001, India |
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| Abstract: | An efficient one-pot synthesis of Nα-protected S-linked 1,3,5-triazine tethered peptidomimetics is described. The protocol involves a three-component condensation reaction employing Nα-protected amino alkyl isothiouronium salt, formaldehyde and amino acid ester or aryl amine as reactants. Various aryl amines with substitutions and amino acids with simple as well as bifunctional side chains were employed to obtain triazine tethered peptidomimetics in good yield. |
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| Keywords: | Nα-protected amino alkyl isothiouronium salts Amino acid ester Formaldehyde Dehydrocyclization |
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