A mild synthesis of bis(indolyl)methanes using a deep eutectic solvent |
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Authors: | Scott Handy Nicole M Westbrook |
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Institution: | Department of Chemistry, Middle Tennessee State University, Murfreesboro, TN 37132, United States |
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Abstract: | Deep eutectic solvents (such as the combination of urea and choline chloride) are effective solvents/organocatalysts for the condensation of indole and aryl or alkenyl aldehydes to form bis(indolyl)methanes. The reaction conditions are quite mild and do not require additional Bronsted or Lewis acid catalyst, though they fail with ketones or aliphatic aldehydes. Given the inexpensive, non-toxic, and recyclable nature of the DES, these reaction conditions are simple and highly environmentally friendly. |
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Keywords: | Organocatalysis Condensation reaction Deep eutectic Indoles |
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