7,8,9,10-Tetrahydropyrrolo[2,1-a]isoquinolines in the search for new indolizine derivatives |
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| Authors: | Mino R. Caira Marcel Mirel Popa Constantin Draghici Loredana Barbu Denisa Dumitrescu Florea Dumitrascu |
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| Affiliation: | 1. Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa;2. Center for Organic Chemistry C.D. Nenitescu, Romanian Academy, Spl. Independentei 202B, Bucharest 060023, Romania;3. Faculty of Applied Chemistry and Materials Science, ‘Politehnica’ University of Bucharest, Polizu Street 1-7, 011061 Bucharest, Romania;4. Faculty of Pharmacy, ‘Ovidius’ University, Aleea Universitatii nr.1, Campus Corp B, Constantza 900470, Romania |
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| Abstract: | 7,8,9,10-Tetrahydropyrrolo[2,1-a]isoquinolines were obtained by 1,3-dipolar cycloaddition reactions of their corresponding N-ylides with olefinic (acrylonitrile) and symmetrical or non-symmetrical acetylenic dipolarophiles (methyl/ethyl propiolate, dimethyl acetylenedicarboxylate). Also, stable 5,6,7,8-tetrahydroisoquinolinium dicyanomethylide was isolated and characterized by X-ray diffraction analysis. |
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| Keywords: | Indolizine 1,3-Dipolar cycloaddition Pyrrolo[2,1-a]isoquinoline Dicyanomethylide X-ray diffraction |
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