A phenyldilactone,bisnorsesquiterpene, and cytotoxic phenolics from Maytenus senegalensis leaves |
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| Authors: | Festus Basden Chiedu Okoye Abdessamad Debbab Victor Wray Charles Okechukwu Esimone Patience Ogoamaka Osadebe Peter Proksch |
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| Institution: | 1. Institut für Pharmazeutische Biologie und Biotechnologie, Universität Düsseldorf, Düsseldorf, Germany;2. Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, 420281 Awka, Anambra State, Nigeria;3. Helmholtz Centre for Infection Research, Inhoffenstrasse 7, D-38124 Braunschweig, Germany;4. Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, 420281 Awka, Anambra State, Nigeria;5. Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, 410001 Nsukka, Enugu State, Nigeria |
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| Abstract: | Maytenus senegalensis Lam. (Celastraceae) leaves are traditionally used in West Africa for the management of cancer and other disorders associated with inflammation. In this study, bioactivity-guided fractionation of the methanol leaf extract of Maytenus senegalensis led to the isolation of 11 compounds, including the new phenyldilactone, maysedilactone (1). All isolated compounds were tested for cytotoxicity against mouse lymphoma cell line (L5178Y). Only (−) epigallocathechin showed high cytotoxicity and completely inhibited cell growth at the investigated dose of 10 μg/mL. This result supports the claimed efficacy of Maytenus senegalensis leaf extract in ethnomedicinal treatment of cancer. |
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| Keywords: | Maytenus senegalensis Celastraceae Cytotoxicity Lactones Bisnorsesquiterpenes Phenolics |
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