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Solvent-free asymmetric conjugate addition of malonates to enones using a diaminomethylenemalononitrile organocatalyst |
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| Authors: | Shin-ichi Hirashima Takaaki Sakai Kosuke Nakashima Nana Watanabe Yuji Koseki Kanako Mukai Yohei Kanada Norihiro Tada Akichika Itoh Tsuyoshi Miura |
| Institution: | 1. Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan;2. Gifu Pharmaceutical University, 1-25-4, Daigaku-nishi, Gifu 501-1196, Japan |
| Abstract: | Diaminomethylenemalononitrile organocatalyst 1 efficiently promotes the asymmetric conjugate addition of malonates to α,β-unsaturated ketones to afford the corresponding addition products in high to excellent yields with up to 98% ee. |
| Keywords: | Organocatalyst Michael addition Solvent-free Diaminomethylenemalononitrile Malonate |
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