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A novel and efficient amidation of 2-aminothiazole |
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| Authors: | Minho Choi Sun-Woo Won Hyeju Jo Mayavan Viji Seung-Yong Seo Yeon-Ju Lee Hyi-Seung Lee Heesoon Lee Jin Tae Hong Young-Shin Kwak Jae-Kyung Jung |
| Affiliation: | 1. College of Pharmacy and Medicinal Research Center (MRC), Chungbuk National University, Cheongju 362-763, Republic of Korea;2. College of Pharmacy, Korea University, Sejong 339-700, Republic of Korea;3. College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 406-779, Republic of Korea;4. Korea Ocean Res & Dev Inst, Ansan 426-44, South Korea |
| Abstract: | A facile and efficient method has been developed for the synthesis of novel thiazolyl carboxamide derivatives by direct reaction of the corresponding esters and 2-aminothiazole. Treatment of 2-aminothiozole with various carboxylic esters in the presence of t-butylmagnesium chloride provides the biologically significant thiazolyl carboxamide derivatives in good to excellent yields. |
| Keywords: | Amide 2-Aminothiazole Carboxamide Transamidation t-Butylmagnesium chloride |
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