An enantioselective synthesis of a MEM-protected aetheramide A derivative |
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| Authors: | Arun K Ghosh Kalapala Venkateswara RaoSiddhartha Akasapu |
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| Institution: | Department of Chemistry, and Department of Medicinal Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, United States |
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| Abstract: | Aetheramides A and B are very potent anti-HIV agents. An enantioselective synthesis of a MEM-protected aetheramide A derivative is described. The synthesis was accomplished in a convergent and stereoselective manner. The key reactions involved asymmetric dihydroxylation, asymmetric allylation, asymmetric syn-aldol reactions, and asymmetric hydrogenation. |
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| Keywords: | Anti-HIV Anticancer Natural product Asymmetric synthesis Aetheramides |
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