CuI/glycerol mediated stereoselective synthesis of 1,2-bis-chalcogen alkenes from terminal alkynes: synthesis of new antioxidants |
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Authors: | Lóren CC Gonçalves Francine N Victória David B Lima Pedro MY Borba Gelson Perin Lucielli Savegnago Eder J Lenardão |
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Institution: | 1. LASOL, CCQFA, Universidade Federal de Pelotas—UFPel, PO Box 354, 96010-900 Pelotas, RS, Brazil;2. Grupo de Pesquisa em Neurobiotecnologia—GPN, CDTec, Universidade Federal de Pelotas, UFPel, Pelotas, RS, Brazil |
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Abstract: | (E)-1,2-Bis-chalcogen alkenes were stereoselectively prepared in good yields by the addition of diorganyl dichalcogenides to terminal alkynes using CuI/Zn/glycerol as a recyclable catalytic system. The antioxidant activity in vitro of four (E)-1,2-bis-chalcogen alkenes synthesized was evaluated and (E)-1,2-bis-(4-methoxyphenylselanyl)styrene 3b presented excellent activity. The catalytic system used in the synthesis was recovered and used directly up to 5 cycles without loss of activity. |
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Keywords: | Catalysis Bis-chalcogen alkenes Glycerol CuI/Zn Antioxidant |
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