Solid-phase synthesis of benzazoles,quinazolines, and quinazolinones using an alkoxyamine linker |
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| Authors: | Kota Yamaguchi Takeshi Noda Yusuke Higuchi Naoyuki Aoki Rika Yamaguchi Miwa Kubo Kenichi Harada Yoshiyasu Fukuyama Hideaki Hioki |
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| Affiliation: | 1. Faculty of Education, Gunma University, Maebashi, Gunma 371-8510, Japan;2. Department of Applied Bioscience, Kanagawa Institute of Technology, Atsugi, Kanagawa 243-0292, Japan;3. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan |
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| Abstract: | An alkoxyamine linker was applied for the solid-phase synthesis of benzazoles, quinazolines, and quinazolinones. Aromatic aldehydes were anchored by aldoxime linkage. After some reactions on a solid support, the products were cleaved with paraformaldehyde under the acidic conditions to afford the corresponding aldehydes, which were subsequently subjected to oxidative coupling with 2-substituted anilines under air atmosphere to give the desired compounds. |
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| Keywords: | Solid-phase synthesis Alkoxyamine Linker Benzimidazole Quinazoline Quinazolinone |
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