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A mild and efficient method for large scale synthesis of 3-aminocoumarins and its further application for the preparation of 4-bromo-3-aminocoumarins |
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| Authors: | Deb K. Das Satavisha Sarkar Musawwer Khan Md. Belal Abu T. Khan |
| Affiliation: | 1. Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781 039, India;2. Vice-Chancellor, Aliah University, DN-18, 8th Floor, Sector V, Salt Lake, Kolkata 700 091, West Bengal, India;3. Department of Chemistry, Aligarh Muslim University, Aligarh, U.P. 202 002, India |
| Abstract: | A wide variety of 3-aminocoumarins have been synthesized in large scale from the corresponding 3-acetamidocoumarins by regioselective cleavage of carbon–nitrogen bond using 70% sulfuric acid under reflux conditions. The synthesized 3-aminocoumarins were further brominated regioselectively at the 4-position of 3-aminocoumarin using BDMS as brominating agent. |
| Keywords: | 3-Acetamidocoumarins 3-Aminocoumarins Salicylaldehydes N-Acetylglycine Sulfuric acid |
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