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Catalyst- and chromatography-free synthesis of pyrrole-substituted indolinone derivatives in water |
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| Authors: | Nazim A.A. Ahmad Sunil M. Rokade Ashok M. Garande Prakash M. Bhate |
| Affiliation: | Department of Dyestuff Technology, Institute of Chemical Technology (Formerly UDCT), N. P. Marg, Matunga, Mumbai 400 019, Maharashtra, India |
| Abstract: | Pyrrole-substituted indolinone derivatives were synthesized by the reaction of 4-hydroxyproline and isatin derivatives in water under catalyst-free conditions. The main advantages of this protocol besides the use of water as a solvent include short reaction time, practical simplicity, and high yield. |
| Keywords: | 3-(Pyrrol-1-yl)-indolin-2-one Isatin trans-4-Hydroxy-l-proline Green chemistry |
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