An inhibitor of the adipogenic differentiation of 3T3-L1 cells,yoshinone A,and its analogs,isolated from the marine cyanobacterium Leptolyngbya sp. |
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| Authors: | Toshiyasu Inuzuka Keita Yamamoto Arihiro Iwasaki Osamu Ohno Kiyotake Suenaga Yoshinori Kawazoe Daisuke Uemura |
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| Affiliation: | 1. Life Science Research Center, Gifu University, Yanagido, Gifu 501-1193, Japan;2. Facultyof Science, Kanagawa University, Hiratsuka, Kanagawa 259-1293, Japan;3. Department of Chemistry, Keio University, Yokohama, Kanagawa 223-8522, Japan;4. Research Institute of Natural-Drug Leads, Kanagawa University, Hiratsuka, Kanagawa 259-1293, Japan |
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| Abstract: | Three novel compounds, yoshinones A, B1, and B2, were isolated from the marine cyanobacterium Leptolyngbya sp., and their structures were elucidated by NMR spectral analysis. Yoshinone A, but not yoshinone B1 or B2, inhibited the differentiation of 3T3-L1 cells into adipocytes. In addition, yoshinone A did not exhibit cytotoxicity, suggesting that yoshinone A may be useful in studies on the treatment of obesity. |
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| Keywords: | Yoshinone γ-Pyrone Adipogenesis Obesity 3T3-L1 cells |
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