Four new minor alkaloids from the seeds of Strychnos nux-vomica |
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Authors: | Yu-sheng Shi Yun-bao Liu Shuang-gang MaLi Li Jing QuYong Li Shi-shan Yu |
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Institution: | State Key Laboratory of Bioactive Substance and Function of Natural Medicines and Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People’s Republic of China |
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Abstract: | Four new minor alkaloids, stryvomicine A (1), deoxy-isostrychnine-chloromethochloride (2), β-colubrine-chloromethochloride (3) and α-colubrine-chloromethochloride (4) were isolated from the seeds of Strychnos nux-vomica. Stryvomicin A possesses an unprecedented 6/5/7/8/6/7/6 heptacyclic ring system, which is the first example of the linkage of the C3–O–C26–N4 bond in strychnan-type alkaloids. Compound 5 induced the occurrence of autophagy and might have potential implications in autophagy related diseases. |
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Keywords: | Strychnos nux-vomica Indole alkaloid ECD calculation Autophagy |
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