Bromolactonization of alkenoic acids mediated by V2O5 via bromide to bromenium in situ oxidation |
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| Authors: | McKenzie L. Campbell Samuel A. Rackley Lauren N. Giambalvo Daniel C. Whitehead |
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| Affiliation: | Department of Chemistry, Clemson University, Clemson, SC 29634, USA |
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| Abstract: | An efficient protocol for the bromolactonization of alkenoic acids is presented that obviates the use of molecular bromine or exogenous bromenium sources. Vanadium (V) oxide catalyzes the in situ oxidation of bromide salts to bromenium (Br+) in a process mediated by urea–hydrogen peroxide complex. Initial mechanistic investigations indicate that the presence of urea does not accelerate the halolactonization reaction. |
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| Keywords: | Bromolactonization Halenium equivalent Alkenoic acid Vanadium oxide |
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