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Microwave-assisted transition-metal-free intramolecular Ullmann-type O-arylation in water for the synthesis of xanthones and azaxanthones |
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| Authors: | Xiaojin Zhang Li Yang Yue Wu Jianyao Du Yingle Mao Xiao Wang Shijie Luan Yonghua Lei Xiang Li Haopeng Sun Qidong You |
| Affiliation: | 1. Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China;2. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China;3. Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China;4. Department of Organic Chemistry, School of Science, China Pharmaceutical University, Nanjing 210009, China |
| Abstract: | An efficient, rapid, and green method was developed for the synthesis of xanthones and azaxanthones. Transition-metal-free intramolecular Ullmann-type O-arylation reaction of 2-halo-2′-hydroxybenzophenones in the presence of TBAOH as base under microwave irradiation in water afforded the desired xanthones and azaxanthones in short reaction time in excellent yields. |
| Keywords: | Xanthone Azaxanthone Microwave Water Transition-metal-free Green chemistry |
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