Design,synthesis, and evaluation,derivatives of the fat-accumulation inhibitor ternatin: toward ternatin molecular probes |
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| Authors: | Yoshinori Kawazoe Yoko Tanaka Sachikazu Omura Daisuke Uemura |
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| Affiliation: | 1. Research Institute of Natural Drug-Leads, Kanagawa University, 2946 Tsuchiya, Hiratsuka, Kanagawa 259-1293, Japan;2. Department of Chemistry, Faculty of Science, Kanagawa University, 2946 Tsuchiya, Hiratsuka, Kanagawa 259-1293, Japan |
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| Abstract: | Ternatin, a cyclic heptapeptide derived from mushroom, strongly inhibits fat accumulation in 3T3-L1 adipocytes. However, its mechanism of action remains unclear. In this Letter, we designed, synthesized, and evaluated its derivatives for use as molecular probes to isolate its target protein. Finally, we successfully established a pair of ternatin molecular probes. |
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| Keywords: | Ternatin Cyclic peptide Fat accumulation Molecular probe 3T3-L1 cell |
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