Facile synthesis of pyrroles via Rh(II)-catalyzed transannulation of 1-tosyl-1,2,3-triazoles with silyl or alkyl enol ethers |
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| Authors: | Juan Feng Yuanhao Wang Qingong Li Renwang Jiang Yefeng Tang |
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| Institution: | 1. The Department of Pharmacology & Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China;2. The Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China;3. Collaborative Innovation Center for Biotherapy, Tsinghua University, Beijing 100084, China;4. Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China |
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| Abstract: | A novel Rh(II)-catalyzed transannulation of 1-tosyl-1,2,3-triazoles with silyl or alkyl enol ethers has been developed, which enables the facile synthesis of substituted pyrroles in a regiocontrollable manner. Moreover, the methodology could be extended to access 3-pyrrolin-2-one derivatives with silyl ketene acetals used as the reaction partner. |
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| Keywords: | Triazole Pyrrole Enol ether Cycloaddition 3-Pyrrolin-2-one |
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