|
|||||
|
|
First iodocyclization reaction of allene–thioureas: an efficient approach to bicyclic β-lactams |
|
| Authors: | Dinesh R Garud Amol R Jadhav Santosh V Lahore Nilesh M Kahar Rohini R Joshi Ramesh A Joshi Mamoru Koketsu |
| Institution: | 1. Department of Chemistry, Sir Parashurambhau College, Sadashiv Peth, Pune 411030, India;2. Division of Organic Chemistry, National Chemical Laboratory, Pune 411008, India;3. Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan |
| Abstract: | The regioselective iodocyclization reaction of allene–thioureas is described, for the first time, for the synthesis of bicyclic β-lactams. The substitution at the allenyl part heavily influenced the iodocyclization reaction. The iodocyclization reaction of the unsubstituted allene–thioureas afforded six-membered 3-thia-1-dethiacephems whereas, the substituted allene–thiourea afforded seven-membered thiazepines along with five-membered isopenams. |
| Keywords: | β-Lactams Iodocyclization Thiourea Regioselective Allene |
| 本文献已被 ScienceDirect 等数据库收录！ | |