Synthesis of 4-aryl-2,3-dihydropyrroles via Rh-catalyzed intramolecular hydroamino-methylation reaction |
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| Authors: | Xin Zheng Bonan Cao Xumu Zhang |
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| Institution: | Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA |
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| Abstract: | The rhodium-catalyzed intramolecular hydroaminomethylation reaction, generating 4-aryl-2,3-dihydropyrroles, has been developed. Triphenylphosphine has been proved to be the excellent ligand to prepare the dihydropyrrole derivatives in up to 99% yield. This procedure provides an efficient and simple alternative route to synthesize 4-aryl-2,3-dihydropyrrole derivatives only in one step. |
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| Keywords: | Hydroaminomethylation Dihydropyrrole Intramolecular Rhodium |
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