Solvent- and transition metal-free synthesis of spiro[cyclopropane-1,3-oxindoles] from cyclic diazoamides |
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Authors: | Sengodagounder Muthusamy Rajagopal Ramkumar |
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Institution: | School of Chemistry, Bharathidasan University, Tiruchirappalli 620 024, India |
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Abstract: | A highly efficient method to synthesize spirocyclopropane-1,3-oxindoles] from cyclic diazoamides and mono-substituted or 1,2-disubstituted alkenes under solvent- and transition metal-free conditions is reported. The reaction offers proficient access to synthetically useful and biologically important spirocyclopropane-1,3-oxindoles]. The advantageous features of this sustainable method are being metal-free, shorter reaction time, cost-effectiveness, eco-friendliness and excellent yields. The selectivity and yield are comparable with transition metal-catalyzed cyclopropanation reactions. |
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Keywords: | Metal-free Diazoamides Oxindoles Spirocyclopropanes |
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