Ligand-free palladium assisted insertion of isocyanides to urea derivatives for cascade synthesis of phenylamino-substituted quinazolinones |
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| Authors: | Siddharth Sharma Abhilasha Jain |
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| Affiliation: | 1. Department of Chemistry, U.G.C. Centre of Advance Studies in Chemistry, Guru Nanak Dev University, Amritsar 143005, India;2. Department of Chemistry, St. Xavier’s College, Mumbai 400001, India |
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| Abstract: | Palladium catalyzed cascade coupling of substituted urea derivatives and tert-butyl isocyanide for the efficient synthesis of phenylamino-substituted quinazolinones has been developed in moderate to good yields. This method provides a short and alternative approach for the synthesis of quinazolinones derivatives which are valuable compounds with biological and pharmacological potentials. A plausible mechanistic scheme is proposed. |
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| Keywords: | Isocyanide insertion Metal catalyzed Quinazolinone |
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